While this interface shows every option at one screen, I imagine a simple dropdownlist would be much more user friendly. This is for the normal player: normal rooms dont have gravity jump and speed mods unfortunately. For ets there could be a secondary dropdownlist for those three: you dont really need [S101] and representative numbers like multiples of 10 and 25 are enough.
Instead of 30 tags you have 2 dropdownlists where each selection gets added to a secondary line below the room title displaying which tags have been selected.
Behind the scenes you could have a few lines of code autoremove conflicting tags like (god cancelling vamp,nc,nr,vanilla), (dmg1 cancelling dmg2,dmg3), (IA cancelling AD, NG) etc.
A player in normal rooms really only needs one dropdownlist with all of the tags, scrollable. Or perhaps more, separated by purpose: ranged weapons, melee weapons, health changes (including HPAP%, DMG1/2/3 and the others)
I dont think variety is a disadvantage, especially in a game that needs to constantly evolve to a community. Removing the fun mode tags for normal players years ago is still something i consider a mistake even if they werent used as much.
I see 27 tags in the ET room settings which could all be in a single dropdownlist.